C3394
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C3394
Sigma
Cordycepin
from Cordyceps militaris
| Synonym: | 3′-Deoxyadenosine |
| CAS Number: | 73-03-0 |
| Linear Formula: | C10H13N5O3 |
| Molecular Weight: | 251.24 |
| Beilstein Registry Number: | 35194 |
| EC Number: | 200-791-4 |
| MDL number: | MFCD00037998 |
| PubChem Substance ID: | 24892611 |
Description
| Biochem/physiol Actions | Converted to cordycepin 5′-triphosphate. It is incorporated into nucleic acid by poly(A) polymerase, but because it lacks a 3′-hydroxyl group, it causes chain termination. It can be used for 3′-end labeling of RNA. |
Properties
| biological source | from Cordyceps militaris |
| Gene Information | rat ... Adora1(29290) |
| storage temp. | −20°C |
Safety
| Personal Protective Equipment | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
| Hazard Codes | T |
| Risk Statements | 25-36/37/38 |
| Safety Statements | 26-45 |
| RIDADR | UN2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | AU7358610 |
References
| reference | Duncan, R.F., Cordycepin blocks recovery of non-heat-shock mRNA translation following heat shock in Drosophila. Eur. J. Biochem. 233, 784-792, (1995) Abstract |
| Ioannidis, P., et al., The polyadenylation inhibitor cordycepin (3'dA) causes a decline in c-MYC mRNA levels without affecting c-MYC protein levels. Oncogene 18, 117-125, (1999) Abstract | |
| Kodama, E.N., et al., Antileukemic activity and mechanism of action of cordycepin against terminal deoxynucleotidyl transferase-positive (TdT+) leukemic cells. Biochem. Pharmacol. 59, 273-281, (2000) Abstract | |
| Merck | Merck 13,2555 |
| Beilstein | Beil. 26,IV,3594 |
